Robust processor allocation for independent tasks when dollar cost for processors is a constraint

Includes bibliographical references (pages 9-10).In a distributed heterogeneous computing system, the resources have different capabilities and tasks have different requirements. Different classes of machines used in such systems typically vary in dollar cost based on their computing efficiencies. Makespan (defined as the completion time for an entire set of tasks) is often the performance feature that is optimized. Resource allocation is often done based on estimates of the computation time of each task on each class of machines. Hence, it is important that makespan be robust against errors in computation time estimates. The dollar cost to purchase the machines for use can be a constraint such that only a subset of the machines available can be purchased. The goal of this study is to: (1) select a subset of all the machines available so that the cost constraint for the machines is satisfied, and (2) find a static mapping of tasks so that the robustness of the desired system feature, makespan, is maximized against the errors in task execution time estimates. Six heuristic techniques to this problem are presented and evaluated

On and Off Chip Capacitor Free, Fast Response, Low Drop-out Voltage Regulator

A low drop-out [LDO] voltage regulator with fasttransient response which does not require capacitor for properoperation is proposed in this paper. Recent cap-less LDOs donot use off chip capacitor but instead they use on chip capacitorwhich occupy large area on chip. In the proposed LDO this onchip capacitor is also avoided. A novel secondary local feed-backtechnique is introduced which helps to achieve a good transientresponse even in the absence of output capacitor. Further aself compensating error amplifier is selected to eliminate theneed of compensating capacitor. Stability analysis shows that theproposed LDO is stable with a phase margin of 78 0 . The proposedLDO is laid out using Cadence spectre in 180 nm standard CMOStechnology. Post layout simulation is carried out and LDO gives6mV/V and 360μV /mA line and load regulation respectively. Anundershoot of 120 mV is observed during the load transitionfrom 0 mA to 50 mA with 1 μs transition time, however LDO isable to recover within 1.4μs. Since capacitor is not required inany part of design, it occupies only 0.010824 mmXmm area on chip

An Observational study on Siddha Diagnostic Tools including Line of Treatment and Dietary Regimen in the Patients of Sileththuma Vippuruthi (Lung Cancer)

The Aim of this study is to evaluate the significance of the disease SILETHTHUMA VIPPURUTHI (Lung Cancer) with help of siddha parameters Ennvagai thervu, Manikkadai Nool, Yaakkai Ilakkanam and Panchapatchi Sasthiram, Jothidam. From Yugi Vaithiya Chinthamani – 800, Sileththuma Vippuruthi is one type of Vippuruthi Noigal, characterized by cough with or without blood, weight loss, Anaemia, Frequent respiratory disorders, Fatigue, Swollen lymph nodes, Swollen face and neck, clubbing and cyanosis. The author had collected review of literature, definition, aetiology and classifications from various texts. For the clinical study 40 cases (OPD) were for the observational per the inclusion and exclusion criteria and the informed consent were obtained from the patients. Case sheet proforma were maintained for 40 cases. The author took the study in his OPD under the guidance of guide and other faculties. Laboratory investigations also were carried out during the study. Ennvagai thervu, Yaakkaii lakkanam, Manikkadai nool, Jothidam and Panchapatchi sasthiram of the patients were evaluated in the study. In this study, following data were observed and discussed for the 40 cases. Among 40 cases, 18% cases had cough with blood, 83% cases had cough without blood, 63% cases had weight loss, 90% cases had anaemia, 5% cases had fatigue, 100% cases had frequent respiratory disorders, 75% cases had swollen lymph nodes, 55% cases had swollen face and neck, 33% cases had clubbing, 38% of cases were between 40 to 50 years old. 78% of cases were taking mixed diet. 50% of cases were lower class patients. 65% of cases had Melivu udalvanmai. 65% of cases were Piththa Kaba dhegi. 50% of cases were from Marutha nilam. 38% of cases came in Pinpani Kaalam. 100% of cases, Praanan (Uyir kaatru), Viyaanan (Thozhil Kaatru) and Samaanan (Niravu Kaatru) was affected. 100% of cases, Ranjagam (VannaEri Anal); Saathagam (Aatralangi Anal) was affected. 100% of cases, Avalambagam (Ali Iyyam) were affected. 100% of cases, Saaram, Senneer, Oon and Kozhuppu was affected. 75% of cases had Kaba Pithham Naadi. 80% of cases had Midhaveppam and 100% of cases had Kazhalai in Sparisam. 75% of cases had MaaPadithal present in tongue. 75% of cases had ThaazhnthaOli. 65% of cases had pale yellowish coloured urine; 83% of cases had ammonia odour urine; 75% of urine had Deposits. 70% of cases had Kaba Piththam Neikuri. 70% of cases had 7½ fbs wrist circumference. 55% of cases shows Kabam in panjapatchi saasthiram. 53% of cases shows association of guru with 6th baavagam. CONCLUSION: By this study, the cases of Sileththuma vippuruthi (lung cancer) were examined through siddha diagnostic parameters also with parallel modern diagnosis was derived through routine blood tests, routine urine tests and special investigations such as CT, PET scan, FNAC. From the measured values, 75% of Sileththuma vippuruthi could be examined through Siddha diagnostic parameters. This study would provide the documentary data of various parameters including eight fold examinations, Nei kuri, Manikkadai nool, Jothidam and Panjapatchi saasthiram to measure the occurrence and seviority of the disease. It would be helpful for the future reference and low cost effective to diagnose the lung cancer. It may encourage the future siddha physicians to rule out the diseases with the siddha diagnostic parameter itself. By diagnosing the disease it helps to treat by choosing medicines and helpful in noticing the prognosis of the disease. It shows the way of development of the Siddha medicine in diagnostic aspects

Structural elucidation, theoretical insights and thermal properties of three novel multicomponent molecular forms of gallic acid with hydroxypyridines

Development of novel drug for manipulating the physicochemical properties of the API by obtaining their multicomponent forms is a challenging task in the pharmaceutical industry. Novel multicomponent crystal forms of gallic acid with three hydroxypyridines have been prepared by liquid assisted grinding and slow evaporation of the solvent. Preliminary PXRD and FTIR characterizations were carried out to confirm the interactions between the components, then the three dimensional molecular structures were confirmed through single crystal X-ray diffraction method. Structural studies clearly revealed the three distinct molecular crystal forms of gallic acid with hydroxypyridines. The molecular structures exhibit O�H�O, N�H�O and C�H�O intermolecular hydrogen bond interactions, which results different supramolecular motifs. Further, intermolecular interactions were quantified through Hirshfeld surface analysis, which revealed the dominance of O�H and H�H interactions. Computation of interaction energies between the molecules and analysis of three dimensional energy frameworks quantifies the molecular packing. The density functional theory calculations were employed to optimize the structural coordinates, which substantiate the experimental results. Low value of HOMO-LUMO energy gap signifies the promising electronic properties of the molecules. The chemical reactive sites were further identified on the molecular electrostatic potential surface. Finally, thermal properties of the crystals were studied using thermogravimetric analysis

Structural elucidation, theoretical insights and thermal properties of three novel multicomponent molecular forms of gallic acid with hydroxypyridines

Development of novel drug for manipulating the physicochemical properties of the API by obtaining their multicomponent forms is a challenging task in the pharmaceutical industry. Novel multicomponent crystal forms of gallic acid with three hydroxypyridines have been prepared by liquid assisted grinding and slow evaporation of the solvent. Preliminary PXRD and FTIR characterizations were carried out to confirm the interactions between the components, then the three dimensional molecular structures were confirmed through single crystal X-ray diffraction method. Structural studies clearly revealed the three distinct molecular crystal forms of gallic acid with hydroxypyridines. The molecular structures exhibit O-H-O, N-H center dot center dot center dot O and C-H center dot center dot center dot O intermolecular hydrogen bond interactions, which results different supramolecular motifs. Further, intermolecular interactions were quantified through Hirshfeld surface analysis, which revealed the dominance of O center dot center dot center dot H and H center dot center dot H interactions. Computation of interaction energies between the molecules and analysis of three dimensional energy frameworks quantifies the molecular packing. The density functional theory calculations were employed to optimize the structural coordinates, which substantiate the experimental results. Low value of HOMO-LUMO energy gap signifies the promising electronic properties of the molecules. The chemical reactive sites were further identified on the molecular electrostatic potential surface. Finally, thermal properties of the crystals were studied using thermogravimetric analysis. (C) 2020 Elsevier B.V. All rights reserved

Synthesis, molecular docking and anti-mycobacterial evaluation of new imidazo1,2-a]pyridine-2-carboxamide derivatives

New anti-tubercular agents, imidazo1,2-a]pyridine-2-carboxamide derivatives (5a-q) have been designed and synthesized. The structural considerations of the designed molecules were further supported by the docking study with a long-chain enoyl-acyl carrier protein reductase (InhA). The chemical structures of the new compounds were characterized by IR, H-1 NMR, C-13 NMR, HRMS and elemental analysis. In addition, single crystal X-ray diffraction has also been recorded for compound 5f. Compounds were evaluated in vitro against Mycobacterium tuberculosis H37Rv, and cytotoxicity against HEK-293T cell line. Amongst the tested compounds 5j, 5l and 5q were emerged as good anti-tubercular agents with low cytotoxicity. The structure-anti TB activity relationship of these derivatives was explained by molecular docking. (C) 2014 Elsevier Masson SAS. All rights reserved

Synthesis, molecular docking, antimycobacterial and antimicrobial evaluation of new pyrrolo3,2-c]pyridine Mannich bases

In this report, we describe the synthesis and biological evaluation of a new series of pyrrolo3,2-c]pyridine Mannich bases (7a-v). The Mannich bases were obtained in good yields by one-pot three component condensation of pyrrolo3,2-c]pyridine scaffold (6a-c) with secondary amines and excess of formaldehyde solution in AcOH. The chemical structures of the compounds were characterized by H-1 NMR, C-13 NMR, LC/MS and elemental analysis. Single crystal X-ray diffraction has been recorded for compound 7k (C23H29ClN4](+2), H2O). The in vitro antimicrobial activities of the compounds were evaluated against various bacterial and fungal strains using Agar diffusion method and Broth micro dilution method. Compounds 7e, 7f, 7r, 7t, and 7u were showed good Gram-positive antibacterial activity against S. aureus, B. flexus, C sporogenes and S. mutans. Furthermore, in vitro antimycobacterial activity was evaluated against Mycobacterium tuberculosis H37Rv (ATCC 27294) using MABA. Compounds 7r, 7t, and 7u were showed good antitubercular activity against Mtb (MIC >= 6.25 g/mL). Among the tested compounds, 14(4-chloro-2-(cyclohexylmethyl)-1H-pyrrolo3,2-clpyridin-3-yl)methyl) piperidine-3-carboxamide (7t) was showed excellent antimycobacterial activity against Mtb (MIC <0.78 mu g/mL) and low cytotoxicity against the HEK-293T cell line (SI 25). Molecular docking of the active compounds against glutamate racemase (Murl) and Mtb glutamine synthetase were explained the structure-activity observed in vitro. (C) 2017 Elsevier Masson SAS. All rights reserved